EvaluatePharma - Roche - Worldwide

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Expert integration of financial and product data across historic and forecast timeframes (1986 to 2016) delivers a vast array of analytics by product, company, therapy area, EphMRA ATC code, technology, patent status, deals, license revenues and much more.

Company Profile



Profile	Roche, a family controlled, Swiss healthcare company. Business segments include: Pharmaceuticals and Diagnostics. 16 APR 2009: Roche acquired Genentech on 26 MAR 2009. Within EvaluatePharma, Genentech is classified as an overlapping inactive company and its product sales (1986-2009) overlap with Roche. Roche owns >50% of Chugai and consolidates 100% of the sales.
Listed or Private Company	Listed
Company Classification	Global Majors
Company Website	Website

Full Company Profile Information

EventAnalyzer - Last Key Event


Closing Price DateClosing Price Date	EventAnalyzer Note	Market Cap (US $m)	Change (%)	Change (+$m)
7/26/2010	26 Jul: Collins Stewart states that a company presentation on 22 Jul provides little clarity on pipeline and restructuring issues.	104,993	-1.1%	-1,003

Top 3 Products (Worldwide Sales 2007/08)

				Annual Sales WW - Sales		Growth per Year (%)
Rank¹	Product	Generic Name	Therapeutic Subcategory	2007	2008	2008
1	Rituxan	rituximab	Anti-neoplastic MAbs	4,602²	5,481³	+19%
2	Avastin	bevacizumab	Anti-neoplastic MAbs	3,426⁴	4,818⁵	+41%
3	Herceptin	trastuzumab	Anti-neoplastic MAbs	4,048⁶	4,712⁷	+16%

Note: Shaded Cells⁸

RX Sales Chart

Roche	Data		Growth
	2007	2008	2008
Revenues By Segment
Pharmaceuticals
Pharmaceuticals Sales (In-depth)
Rx & OTC Pharmaceuticals
Prescription (Rx) Pharmaceuticals⁹	30,661¹⁰	33,247¹¹	+8%

Therapy Area Focus in 2008

Roche
	2008
WW Rx & OTC Sales By Therapy Area
Main Categories
Blood	1,573
Cardiovascular	375
Central Nervous System¹²	998¹³
Dermatology¹⁴	249
Endocrine	384
Gastro-Intestinal	700
Musculoskeletal	1,154
Oncology & Immunomodulators	20,775¹⁵
Respiratory	976¹⁶
Sensory Organs	875
Systemic Anti-Infectives	1,974¹⁷
Other Rx & OTC Pharma	3,212¹⁸

EvaluatePharma® Coverage of Marketed and Pipeline Products


	Product Count
Roche ¹⁹	520

2009 Product Sales analysis
2009 Pharmaceutical Sales
2009 Market Share & Global Ranking
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Search 2 yrs of company press releases


EP Vantage - last 6 months

Therapeutic focus - Melanoma awaiting breakthrough but data approaching (September 10, 2010)

Event - Roche announces timely efficiency drive as Avastin decision looms (September 03, 2010)

Roche and ImmunoGen sent reeling by FDA roadblock (August 27, 2010)

Therapeutic focus - What are plan B options if A-beta Alzheimer's hypothesis is void? (August 19, 2010)

EP Vantage Interview - Pragmatic Evotec takes on metabolic disease (August 17, 2010)

Displaying 5 out of a possible 41 unique stories.
Results Sorted By date
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Ranked on:
Annual Sales WW
2008

Group Total: Equals the sum of values in report based on report grouping.

Note: Where Top 5,10,100 etc filters have been applied, the aggregate value relates to the total of the original unfiltered group - not the displayed filtered data. Where n/a appears, a value has been hidden but is included in Group Total.

Examples:

e.g. Top 100 drugs reports. These are not grouped but are filtered to show only the top 100 products by sales in a particular year. The Group Total displayed is equal to the sum of all data within Evaluate Pharma - not just the top 100 products i.e. total market size.

e.g. Global Majors - Top 10 products. Report is grouped by Company and filtered to show only the top 10 products by sales in a particular year. Group Totals are displayed for each company and are equal to the sum of all available data for that company - not just the top 10 products.

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XXXXXX: XXXXXXXXX XXXX XX-X, XXXXX X-X:
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XX XXX XXXXXXXXX XX XXXXXX XX XXXX XX XXX XXX XXX XXX XXX XX XXXXXXX XX XXXXXXXXXXX XXXX XXXXXXXXXX XXXXX-XX XXX XXX XXXXXXXXX XX XXXXXXXX XXXX XXXXXXXXXX XXXXXXXXX XXXXXXXX XXXXX XXXX XXXXXXXXX. XXXX XXXXXXX XX XXXXX XXXXXXXXX XX XXXXXXXXXXXXX XXXX XXXXX. XX XXXXXX XX XXXXXX XX XXXX XX XXX XXX XX XXXX.

XX XXX XX XXXXXXXXXXX XXXXXXXXXXX XXXX XXX XXX XXXXXXXXX XXX XXXXXXXXXX XXXXXXXXXXXX XXX X XXXXXXXXX XXXX XXX XXX XXX XX XXXXXXX XX XXXXXXXXXXX XXXX XXX-XX XX XX X XXXXXX XXXXX XX XXXXXXXX XXXX XXXXXXXXXXXX XXXXXXXXXX (X XXXX XX XXXXX XXXXXX) XXX XXXX XXXXXXXXXX XXXXXXXXX XXXXX XXXXXXX.

…XXXXXXX XX XXXXX XXXXXXXXX XX XXXXXXXX XXXXX XXXXXX, XXXXXX-XXXX XXXXXXXXXX XXXXX XXXXXX XXX XXXXXXXX XXX XXXX XXXXXXXXXX XXXXXXXXX XXXXX-XXXX XXXXXXXXX XX XXXXXXX XXXX XXXXXXXXXXXX, XXXXXXXX XXXX-XXXXXXXX XX, XXXXXXXX XXXX XXXXXX, XXXXX-XXXX XXXX-XXXXXXXX XXX XXXXXX-XXXX XXXX-XXXXXXXX XXXXXXXXXX XXXXXX XXXXXX XX XXXXXXXXXXX XXXX XXXXXXX XXXXXXXXXXXX XXXXXXXX, XXXXX-XXXX XXX-XXXXXXXX XXXXX, XXXXX-XXXX XXX XXXXXXXX-XXXXXXXXX XXXXXXXX XXXXXXX XXXXXX, XXX XXXXXXX XXXXXXXXXX XXXXXXXX XXXXXX. XXXX XXXXXXX XX XXXXX XXXXXXXXX XX XXXXXXXXXXXXX XXXX XXXXX.

XXXXXXX XX XXXXX XXXXXXXXX XX XXXXX-XXXX XXXXXXXXXX XXXX-XXXXXXXX XX. XXXX XXXXXXX XX XXXXX XXXXXXXXX XX XXXXXXXXXXXXX XXXX XXXXX.

XXXXXXX XXX XXXXXXX XXX XXXXX XXXXXXXXX XX XXXXXXXXXXX XXXXXXX XX XXXXX-XXXX XXXXX XX XXXXXXXXXXX XXXX XXXXXXX XXXXXXXXXXXX XXXXXXXX. XXXXXXX XX XXXXX XXXXXXXXX XX XXXXXXXXXXXXX XXXX XXX XXX XXXXX. XXXXXXX XX XXXXX XXXXXXXXX XX XXXXXXXXXXXXX XXXX XXXXX.

…XX XXX XXXXXXXXX XXX XXXXX XXX XXXXXXXX XXXXXX XX XXXX-XXXX XXXXXXXXX XXXXXX, XXXXX-XXXX XXXXXXXXXXXX XXXXXXXXXX, XXXX XXX XXXX XXXXXX, XXX XXXXXX-XXXXXXXXXX XXXXXXX XXXXXX.

…XXXXXXX XX XXXXX XXXXXXXXX XX XXXXXXXX XXXXXXX, XXXXXXXX-XXXXXXXXX XXXXXXXX XXXXXXX XXXXXX, XXXXXXXXX XXXXX XXXX XXXX XXXXXX, XXX XXXXX XXXX XXXXXXXXXX XXXXXXX XXXXX XXXXXXXXXX XXX XXXXXXXX XXXX XXXXXXXXX. XXXX XXXXXXX XX XXXXX XXXXXXXXX XX XXXXXXXXXXXXX XXXX XXXXX.

XXXXX XXXXXXXXX, XX XXXX, XXXXXX XX XXXXX XXXXXXXXXX:

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X) +XXXX XXXXXX/XXX XXXXX (+XX%).
X) +XXX XXXXX XXXXX (+XXX%).
X) +XXXX XX XXXXX (XXXXXXXXXXXX XX XXXXXXXXX) (+XX%).

XXXXX XX XXXXX: +XXXX (+XX%).

XXXXXXX XXXXXXX:

XXXXXX: XXXXX XXXX XXXXXXXX XXXXXX, XXXX XX:
XX XXXX XXXXX XXXXXXXXX XX XXXXXXXXXX XXX XXXXXXXX XX XXX XXXXX’X XXXXXXX XXXXXXXX XX XXXXXXXXX XX XXXXX XXXXXX. XXXXX XX XXX XXXXXXXXXXXXXXX XXXXXXXX’X XXXXXXXX XXXXXXXXXX XXXX XX% XX XX.X XXXXXXX XXXXX XXXXXX XXX XXX XXXX, XX XX% XX XXXXX XXXXXXXXXXXXXX XXXXX, XXXX XXX XXX XXXXXX XXXXXXXXXXXX XXXXXX-XXXXX XXXXXX. XXXX XX XXXXXXXXXXX, XXX XXXXX XXXXXXXX XXX XXXXXXXXXXX XXXXXXXXXX XXX XXXXX XXXXXXXXX XXXXXXXXXXXX XXXXX XX XXXXXX XXXX XXXXXXXXX XXXXXXXXX XXXXXXX XXXXXXXXX XX XXXXXXX XXX XXXXXX XXXXXXXX XX XXXXXXXXX XXX XXXXX XX XXXXXXXXXX XXX XXXXX XXXXXXXXXX XXXXXXXXX XXXX XX XXXXXXXX/ XXXXXXX, XXXXXXX, XXXXXXXXX, XXXXXXX XXX XXXXXX XXX XX XXXXXXXXXX.

XXXXXX: XX XXXX XXXXXXX (X XXX XXXX):
XXXXXX XXXXX XX XXXXXXX (XXXXXXXXXXX) XXXX XXXXXXXX XXXXXXXXXX XXXX, XXXXXXXXX XX% XX X.X XXXXXXX XXXXX XXXXXX, XXXX XXX XXX XXXXXXX XXXXXXXXXXXX.

XXXXXXX XXXXXXXXX XXXXXXXXXXX XXXXXXX:

XXXXXX: XXXXX XXXX XXXXXXXX XXXXXX, XXXX XX-XX:
XXXXXXX XXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXX XX XXX XXXXXXX XXXXXX XXX XXXX. XX XXXXXXX XXX XX XXXXXXXXXXX XXXXXXXX XX XXXXXXXXX XX XXX XXXXXXX’X XXXXXXXXXX XXXXXXXXXX XXXXXX XXXXXXXXXX, XXXXXXXXXX XXX XXXXXXXXXXX XX XXXXXXX XXXX XXX XXXX XXXXXXXX XXXX XXXXXXXXXXXX XXXXXXXX XX XXX XXXXX XX XXXXXXXXX. XX X XXXXXX, XXXXXXXXX XXX XXXXXXXX XXXX XXXXXXXXXX XXXXXXXXXX XXXXXX XXX XXX XXXX XXXXXX XX XXX XXXXXX XXXXXXXX XXXXXXXX XX XXXXXXX. XX XXXXXXXX XXXXXXXXX XXXXXXXX XXXXXXXXXXX XXXXXXXX XXXX XXX XXX XXX XXXXXXX, XX XXXXXXXXXXX XXXX XXXXXXXXXX XXXXXXXXXXXX, XXX XXX XXXXX-XXXX XXXXXXXXX XX XXXXXXXX XXXX XXXX- XXXXXXXX XXXXXXXXXX XXXXXX XXXXXX. XX XXXX XXXXX XXXXX XX XXXXXXXXXXX XX XXXXXX XXX XXXXXX XXX XXXXXXX XX XXXXXXXX XXX XXXXXXX XX XXXXXXXXXX XXXXXX XXXXXX XXXX XXXXX XXXX XXXX XXX XXXXX XXXXX, XXXXX XXXX XXXX XXXXXXXXX XX XXX XXXX XXXXXXX XX XXX XXXXXXXX XXXXXXX XX XXXXXXXX XXXXXXXX (XXXX) XX XXXX. XXXX XXXXX XXX XXXXXXXX XXXXX XXXXXXXXX XXX XXXXXXX XX XX XXXXXXX XXXXX (XXXXX), XXXXXXX XXXX XXXXXXX XXXXXXXX XXXX XXXXXX XXXXXXXXXXXX XXXXXXXXXXXXX XXXXXXXX XXXXXXXXXXX-XXXX XXXXXXXX XX XXXX XXXXXXX. XX XXXXXXXXX XXXXXXXXX XXXXX X XXXXXXXXXXXXX XXXXXXXXXXX XXXX XXX XXX XXX XXXXXXXX XX XXXXXXX XX XXXXXXXXXXX XXXX XXXXXXXXXX XXXX XX XXXXX XXXXXXXX XXXXX XXXX XXXXXXXXX. XX XXXXXXXX XXXXXXXXX XXXX XXXXXXX XXX XX XXXXXXXX XX XXX XXXXXXXX XX XXXXXXXXXXX XXX XXXXXX XXXX XXXXXXXXXX XXXXXXX (XXXXXXXX) XXXXXXXXXXXX, XXX XXXX XXXXXXXXXX XXXX XX XXXXX XXXXXX, XXXXX XX XXXXXXXX XXXXXXX XXXX X XXXXX XX XXXXXXXX XXXXX (XXXXX). XXXXX XXXXXXX XXX XX XXXXXXXX XX XXXXXXX XXXXX XXX XXXXXXXX XXXX XXXXXXXXXXXX XXX XXX XXXX XXXXXXXXXX XX XXXXXXXX. XX XXXXXXXX XXXXXX XXXXX X XXXXXXXXXXXXX XXXXXXXXXXX XX XXXXX XXX XXXXXXXXX XX XXX XXXXXXX’X XXXXXXXXX XXXXXXXX XX XXXXXXX XXX-XXXXX XXXX XXXX XXXXXX. XXXXX XXXXXXXXX XXXXXXXX XXXX XX XXX XXXXXXXX XX XXXXXXX XX XXXXXX XXX XXXX XXXXXX XXXX XXXXXXXXX XXXXXX XXX XXXX. XX XXXXXXXX XXXXX XXXXXXXXX XXXX X XXXXX XXX XXXXX (XXXXXX-X) XXXXXXXXXXXXX XXXXXXX XX XXXXX-XXXX XXXXXXXXXX XXXX-XXXXXXXX XXXXXX XXXXXX XX XXXXXXXXXXX XXXX XXXXXXXX XXXX XXXXXXXXXXXXXX XXX XXX XXXXXXX XXXXXXXX XX XXXXXXXXXX XXX XXXX XXXXX XXXX XXXXXX XXXXXX XXXXX XXXXXXX XXXXX XXXXXXX XXXXXXXXX (XXXXXXXXXXX-XXXX XXXXXXXX) XXXXXXXX XXXX XXXXXXXXXXXX XXXXX. XXXXX XXXXX XXX XXXXX, XXXXXX-X XX XXX XXXXX XXXXX XX XXXXXXX XXX XXXXXXX XX XXXXXXX XXXXXXXX XXXX XXXXXXXXXXXX XXX XXXXX XXXX XXXXXXXXXX XXXXXX XXXXXX. XX XXXXXXX XXXXX XXXXXXXXX XXX XXXXX XXXXXXX XXXX X XXXXX XXX XXXXX (XXXX XXXX) XXXXXXXXXXXXX XXX XXX XX XXXXXXX XXXX XXXXXXX XXX XXX XXXXXX-XXXX XXXXXXXXX XX XXXXXXXX XXXX XXXXXXXX XXX-XXXXX XXXX XXXX XXXXXX. XXXXX XXX XXXXXXXXXXX XXX XXX XXXX XXX XXXXXXX XXXXXXXX XX XXXXXXX XXXXXXXX, XXXXX XXX XXXXX XXXXXXXX XX XXXXXXXX XXXXXXXX, XXXX XXXXXXXXXXXX XX XXX XXXXXXXXX XXXXXXXXX XX XXXXXXXXXXX-XXXX XXXXXXXX XXX XXXXXXXX XXXX XXXX XXXXXXX XXX XXXXX XX XXXXXXX.

XXXX XX:
XXX XXXXXX XXXXXXXXXXX XXXXXXXXX XXX XXXXXXX XXXXXXXXX XXXXXXXX XXXX XXXX XXX XXXXXXXX XXXXXX XXXX XXXXXX XX,XXX XXXXXXXX XX XXXX XX XXXXXXXXX XXXXXX XXXXX. XXXXX XXX XXXXXXX XX XXXXXXXX XXXX XX XXXXXXX, XXXXXXXX XXX XXXXXXX (XXXXXXX) XXXXXX XXX XXXXXXXXX XX XXXXXX XXXX XXX XXXX XXX XXXXX. XXXXX XXXXXXX XXXX X XXX XXXXXXXX XXXXX XX XXXXXXX XX XXX XXXXX XXXXX XXXXXX XXXXXXX (XXXXX XXX) XXX XXXXXXXX XX XXXX, XXXX XXX XXXXXXX XX XXXXXXX XXXXX XX XXX XXXX XXXXXXX (XXXXX) XXX XX XXXX. XXXXXXXXX XXXXXXXXXX XXXX XXXXXX XX XXXXXXX XXXXXXX XXXXXXXXXX XX XXXX: XXXX, X XXXXXX XXXXX XXX XXXXX XX XXXXXXX XXXXXXXX XXXX XXXXXXXXX XX XXXXXXXX XXXX-XXXXXXXX XXXXXX XXXXXX, XXXXXXX XX XXX; XXXXXXX XXXXXXXXXXX XXX XXX XXXXX XXX XXXXXXX XXXXX XX XXXXX-XXXX XXXXXXXX XXXXXXX XXXXXX XXX XXXXXXXXX XX XXXXXXXX; XXX XXXXXX, X XXXXX XX XXXXX XX XXXXXX XXXXXXX XX XXXXXXXXXXX XXXX XXXXXXXX XXXXXXXXXXXX XX XXXXXXXX XXX XXXXXXXXXXX XXXX XXXXXXX, XXXXXXXXX XX XXXX. XX XXXXXXX XXX XX XXXXXXXXXXX XXXXXXXX X XXXXXXXXX XXXXXXXXXXXXX XXXX XXX XXXXXXX; XXX XXXXXXX XXXXXXXX XXXX XXXXXXXXXX XXXXXXX XXXXXXXXXX XXXX XXX XXXX XX XXXXXX XXX XXXXXX XXXX XXX XXXXXXX XXXXXXXX XXXXXXXX XXXXXXXXXXXX XXX XXXXXXXX.

XXXX XX:
XXXXX XXXXX XXX XXXXXXXX XX XXXXXXXXXX XX XXXXXXXXXXX (XXX XXXXXX XXXXXXXXXX XX XXXXXXX) XX XXX XXX XXXXX XXXXXXXX XXXX XXX XXXX XX XXXXXXXX.

XXXXXX: XXXXXXXXX XXXX XX-X, XXXXX X-X:
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X XXXXXXXXXXXX XXXXXXXX XXXXXXX XXXXXXXXXXX (XXXX) XXX XXXXXXXXX XX XXX XXX XX XXXXXXXXX XX, XXXX XXX XXX XXX XX XXXXXXX XX XXXXXXXXXXX XXXX XXXXXXXXXX XXXXX-XX XXX XXX XXXXXXXXX XX XXXXXXXX XXXX XXXXXXXX XXXXX XXXX XXXXXXXXX. XXXX XXXXXXX XX XXXXX XXXXXXXXX XX XXXXXXXXXXXXX XXXX XXXXX. XXX XXX XXXXXX XXXX XX XXXXXX X, XXXX.
XXXXXXX XX XXXX XXX XXXXXXXXX XX XXX XXX XX XXXXXXX XX, XXXX XXX XXX XXX XX XXXXXXX XX X XXXXXX XXXXX XX XXXXXXXXXX XXXXXXX XXXXXXXX XXXX XXXXXXXXXXXX. XXXX XXXXXXX XX XXXXX XXXXXXXXX XX XXXXXXXXXXXXX XXXX XXXXX. XXX XXX XXXXXX XXXX XX XXX X, XXXX.
XX XXX XXXXXXXXX XXX XXXXX XXX XXXXXXXX XXXXXX XX XXXXX-XXXX XXXXXXXXXXXX XXXXXXXXXX. XXXX XXXXXXX XX XXXXX XXXXXXXXX XX XXXXXXXXXXXXX XXXX XXXXX.

XXXXX XX-XX:
XX XXXXXXXX XX, XXXX, XX XXXXXXXXX XXXX XXXXX, XXXXX’X XXXXX XXXXXXXXXX XXX XXXXX XX XXXXXXX XX XXXXX-XXXX XXXXXXXXXX XXXXXX XXXXXX (XX), XXX XXX XXXXXXX XXXXXXXX XX XXXXXXXXXX XXXXXXXXXXX-XXXX XXXXXXXX (XXX). XXXX XXXXX XX XXXXXXX XX XXXXXXXXXXX XXXX XXXXXXXXXXXX XXXXXX XXXXXXXXXXXXX XXXXXXXXXXX XXXXXXXXXXX XX XXX XXXX XXXXXXXX XXXXX XXXXXXX XXXXX XXXXXXX XXXXXXXXX XXXXXXXX XX XXXXXXXXXXXX XXX XXXXXXX.

XX XXXXXXXX XX, XXXX, XX XXXXXXXX XXXXXXXXXXX XXXXXXXX XXXX XXX X.X XXXX XXX XXXX XXXXXXXXXXXXXX (XXX) XX XXXXXX XXXXXXX XX XXXXXXXXXXX XXXX XXXXXXXXXX XXXXXXXXXXXX XXX XXX XXXXXXXXX XX XXXXXXXX XXX XXXX XXX XXXXXXXX XXXXX XXXXXXXXXXXX XXX XXXXXXXXXX XXXXX XXXXXXXXX XXXXXX XXXXXX XXXXXXXX X (XXXX)-XXXXXXXX XX. XX X XXXXXXXXX XX XXX XXXXXXXXXXX XXXXXXXX, XX XXX XXXXXXXX XX XXXX XXXXXX XXXXXXXXXXX XX XXX XXX, XXXXXXXXX XXX XXXXX XXXXX XXXXXXX XXX XXX XXXXX XXX XXXXXXX, XXXXX XXX XXXXXX X, XXXXX XXX XXXXXXX XX XXXXXXX XX XXXXX-XXXX XXXXXXXXXX XXXX-XXXXXXXX XX. XXXXX XX XXX XXX’X XXXXXX XX XXX XXXXXX XXXXXXXXXXX, XXX XXX XXX XXXXXX XX XXXXXXXX XX XXXXXX XXX XXXXXXXXXXX XXXXXXXX, XXXXXXX XXXXXXXXXX XXXX-XXXXXXXXX XXXXXXX, XX XXXXX XXXX XXXXXXXX.

XX XXXXX XX, XXXX, XX XXXXXXXXX XX XXXXXX XX XXX XXXXXXXXXX XXXXXXXX XXXXX-XXXXXXXXX XXXXXXXXXXXXX XXXXX XXX XXXXXXXX XXXXX XX XXXXXXX (XXXXX) XX XXXXXXXXXXX XXXX XXXXXXXXXXX XXX XXXXXXXXX XXXXXXXXXXXX XX XXXXXXXX XXXX XXXXXXXX, XXX-XXXXXXXX, XXX-XXXXX XXXX XXXX XXXXXX (XXXXX). XXX XXXXXX XXXXXXXXX XXX XXXXXXXXXXXXX XXXXXXXXXXX XXXXXXXXXXX XX XXX XXXXXXX XXXXXXXX XX XXX XXX XXX XXX XXXXXXXXX XXXXX XX XXXXXXX XXXXXXX XX XXX XXXXX (XX XX/XX/XXXXX-XXXXX-XXXXX XXX X.X XX/XX/XXXXX-XXXXX-XXXXX) XXXXXXXX XX XXXXXXXXXXXX XXXXX. XXX XXXXX XXX XXX XXXXXXXXXXX X XXXXXXXXXXXXX XXXXXXXXXXX XXXXXXXXXXXX XX XXXXXXX XXXXXXXX, X XXXXXXXXX XXXXXXXX, XXX XXXXXX XXXX XX XXXXXXX XX XXXXXXXXXXX XXXX XXXXXXXXXXX XXX XXXXXXXXX XXXXXXXXXXXX XXXXXXXX XX XXXXXXXXXXXX XXXXX. XXXXXX XXXXXXXX XX XXXXXXXX XX XXX XXXX XX XXX XXXXX XXXXXXXX XXX XXXX, XXXXXX XXXX XXXXXXXXXX XXXXXXXX XXXXXXXX XXXXX XX XXXX XXXXXXXXXX.

XX XXXXXXXX X, XXXX, XX XXXXXXXXX XXXX XX XXXXXXXXX X XXXXXXXXXXXX XXXXXXXX XXXXXXX XXXXXXXXXXX (XXXX) XX XXX XXX XXX XXXXXXX XX X XXXXXXX XXX XXXXXXXX XXXX XXXXXXXXXX XXXXXXX XXXXXXXXXXXX. XX XXXXXXXX XX XXX XXX, XXX XXXXXXXXXXX XXXXX XX XXXXXXXXXX XXX XX XXXXXXXXXXX XXXXXXXX XXXX XXXXXX XXXXXXXXXXX XXXXXXXX XX XXXXXXXXX XXX XXXXXX XX XXXXX XXXX-XXXXXXXXXXX XXXXXXXX XXXXX XX XXXXXXXXXXX XXXXXXXX XXXXXXXXXX XXXXXXXX XXXXXXX. XX XXXX XX XXXXXXXX X XXXXXX XXXXX XXX XXXXX XX XXX XXXXX XXXX XX XXXX XX XXXXXXXX XXXX XXXXX XXXXXXXXX XXXXXXXXXXXX XXXXXXXXXX XXXX XXXX XXXXXXXX XXXXXXX XXXX XXXXXXXX XX XXXX XXXXXXXXXXXX XXX XXXXXXXXX.
XX XXXXXXXX XX, XXXX, XX XXXXXXXXX XXXX X XXXXX XXX XXXXX (XXXXXX X) XX XXXXXXX, XX XXXXXXXXXXX XXXX XXXXXX, XXXXXXXXXXXXX-XXXXX XX XXXXXXXXXXXX XXXXXXXXXXXXXX XXX XXXXX-XXXX XXXXXXXXX XX XXXXXXXXXX XXXX-XXXXXXXX XX, XXX XXX XXXXXXX XXXXXXXX XX XXXXXXXXXX XXX XXXX XXXXXXXX XXXXX XXXXXXX XXXXX XXXXXXX XXXXXXXXX, XXXXXXXX XX XXX XXXXXXXXXXXXXX XXXXX. XXX XXXXXXX XXXXXXXX XX XXX XXX XXXXXXXX XX XXX XXXXXXXX XXXXXXXXXX XX XXX XXXXX (XXXXXXXXXXXX-XXXXXXXX). XXX XXXXXX XXXXXXX XX XXXXXXX XXX XXXXXXXXXX XXXX XXXXXXXX XXXXXXXXXX XXX XX XXX XXXXXX XXXXXXX XXXX XXXXXXXX.

XXX XXXXXXXX XXXXXXXX XXXXXXXX XXXXXX XXX XXXXX XXXXXXX (XXXXX) XX XXXXXXXXXX XX XXXXXXX XXXXX XXX XXXXX (XXXXX X-XX) XX XXXXXXX XXXX XXXXXXXXXXXX XX XXXXXXXX XXXX XXXXX-XXXXX XXXXX XXXXXX. XXXXXX XXXX, XX XXXXXXXXX XXXX XXX XXXXX XXXXXXXX XX XXXX XXX XXXXX XXXXX XXXXXXXX, XXXXX XX XXXXXXXXXXXXXXX XXXX XX XXXXXXXXXXX XXXX XXXXXXXXXX XXXXXXXXX XXXXX XXXXXXX XXXXXXX XXXXXXXX XXX XXXX XXX XXXXX XXXXXXXX XXX XXXXXX XXXXXXX XXXX XXXXXXXX XX XX XXXXXXXXX XX XXXX XXXXXX XXXX XXXX XX XXX XXXXXXXXXX XXXXXXXXXXX. XX XXXX XXXXXXXXX XXXX XXX XXXXXXX XXXXXXXX XXXXXX XX XXX XX XXXXXXXXXX XXXXXX XXXXXX XX XXX XXXXXXX XXX. XX XXXXXXX XX, XXXX, XX XXXXXXXXX XXXX XXX XXXXX XXXXXXXX XX XXXX XXX XXXXXXX XX XXX XXXXX XXXXX XX XXXXX XXX XXXXXXXXXXXX XX XXXXX XX XXX-XXXXX XXXX. XXX XXXXX XXXXXX XX XXXX XXXXXXXXXXXX XXXX XXXXXX XX XXX XXXXXX XX XXXXXXX XXXXXXXXXXX XXXXXX. XX XXX XXXXXXXX XXXXXX XX XXXXXXX XXXXXXXXXXX XXXXXX XX XXXXXXX XX XXX XXXXX’X XXXXXXXXXXX XXXXXXXXXX XXXX XXX XXX XXXXXXXX XX XX XXX-XXXXX, XXXX XXX XXXXX XXXX XXXXXXXX XXX XXXXX XXX XX XXXXXXXXXX XXXX XXX XXXXX XXXXXXX XXXX XXXX XXXXXX XX XXXXX XXXXX XX XXX XXXXXX XXXXXXX XX XXXX.

XXXX XX:
XXXXX XXX XXXXXXXXXXXXX XX% XX XX% XX XXXXXXXX XX XXXXX-XXXX XXXXXXXXXX XXXX XXXXXX XXX XXX XXXXXXXX XXX XXXXXXX XXXXXXX, XX XXXXXXXX XXXX XXXXXXXXXXX XX XXX XXXXXX XXXXXXX XX XXXX XXX XXXXXXXXXXXXX XX%, XXXXX XX XX-XXXX XXXX XXXXXXXXXXX XXXXXXXXXX XXX XXXX, XXX XX XXXXXXXX XXXXXXXX XX XX XXX XXXXXX XXXXXXX XX XXXX. XXX XX XXX XXXXXXXX XXXX, XXXXXXX XX XX XXXXX X XX/XX/XXXXXX-XXXXXXXXXX, XXXXXX XXX XXXXXX XXXXXXX XX XXXX XXX XXXXXXXXXXXXX XX%, XX-XXXX XXXX XXX XXXXX XXXXXXX XX XXXX. XXX XXXXXXX XXXX XX XXXXXXX XX XXXX XXXXXX XX XX XX/XX, XXXXXXXXXXXX XXXXXXXXXXXXX XXXXX XXXXX XXXXX. XX XXXXX XX, XXXX, XX XXXXXXXXX XX XXXXXX XX XXX XXXXXXXXXX XXXXXXXX XXXXX-XXXXXXXXX XXXXXXXXXXXXX XXXXX XXX XXXXXXXX XXXXX XX XXXXXXX (XXXXX) XX XXXXXXXXXXX XXXX XXXXXXXXXXX XXX XXXXXXXXX XXXXXXXXXXXX XX XXXXXXXX XXXX XXXXXXXX, XXX-XXXXXXXX, XXXXX. XXX XXXXXX XXXXXXXXX XXX XXXXXXXXXXXXX XXXXXXXXXXX XXXXXXXXXXX XX XXX XXXXXXX XXXXXXXX XX XXX XXX XXX XXX XXXXXXXXX XXXXX XX XXXXXXX XXXXXXX XX XXX XXXXX (XX XX/XX/XXXXX-XXXXX-XXXXX XXX X.X XX/XX/XXXXX-XXXXX-XXXXX) XXXXXXXX XX XXXXXXXXXXXX XXXXX. XXX XXXXX XXX XXX XXXXXXXXXXX X XXXXXXXXXXXXX XXXXXXXXXXX XXXXXXXXXXXX XX XXXXXXX XXXXXXXX, X XXXXXXXXX XXXXXXXX, XXX XXXXXX XXXX XX XXXXXXXXXXX XXXX XXXXXXXXXXX XXX XXXXXXXXX XXXXXXXXXXXX XXXXXXXX XX XXXXXXXXXXXX XXXXX. XXXXXX XXXXXXXX XX XXXXXXXX XX XXX XXXX XX XXX XXXXX XXXXXXXX XXX XXXX, XXXXXX XXXX XXXXXXXXXX XXXXXXXX XXXXXXXX XXXXX XX XXXX XXXXXXXXXX.

XX XXXXX-XXXX XXXXXXXXXX XX XXXXXXXX, XX XXXXXXXX XXXXXXX XXXXXXXXXXX XX XXX XXXXXX XXXXXXX XX XXXX XXX XXXXXXXXXXXXX XX%, XXXXX XX XXXXXXXXXX XXXX XXX XXXXX XXXXXXX. XXXX XXXXXXX XX XXXX, XXX XXXXXXXXXX XX XXXXXXXXXX XX XXXXXXXX XXXXXXXXX XXX XXXXXXXX XXXX XX XXXXXXX, XXXXXXX XX X XX/XX/XXXXXX-XXXXXXXXXX, XXX XX-XXXX XXXX XXXX XXXX XX XXXXXXXX XXXXXXXX. XXX X.X. XXXXXXX XXXX XX XXXXXXX XX XXXXXXXXXX XX XX XX XX/XX, XXXXXXXXXXXX XXXXXXXXXXXXX XXXXX XXX XXXXX. XX XXXXXXXX XX, XXXX, XX XXXXXXXXX XXXX XXX XXXXXX X XXXXX XX XXXXXXX XX XXXXXXXXXXX XXXX XXXXXX, XXXXXXXXXXXXX-XXXXX XX XXXXXXXXXXXX XXXXXXXXXXXXXX XXX XXXXX-XXXX XXXXXXXXX XX XXXXXXXXXX XXXX-XXXXXXXX XX XXX XXX XXXXXXX XXXXXXXX XX XXXXXXXXXX XXX XXXX XXXX XXXXXXXX XXXXX XXXXXXX XXXXX XXXXXXX XXXXXXXXX, XXXXXXXX XX XXXXXXXXXXXXXX XXXXX. XXXX XXXX XXXXXX X XXXXX XXXX XXXX XXXX XXXXX, XXX XXXXX-XXXXXXXXX, XXXXXXX-XXXXXXXXXX XXXXX XXX XXXXX, XXXXX XXXXXXXXX XXX XXXX XXXXXX XX XXXXXXX, X X.X XX/XX/XXXXX-XXXXX-XXXXX XXXX XXX X XX XX/XX/XXXXX-XXXXX-XXXX XXXX, XX XXXXXXXXXXX XXXX XXXXXXXXX XXXXXXXXXXXX, XXXX XX XXXXXXXXX XX XXX XXX XX XXX-XXXX, XXX XXX XXXXXXXX XXX XXX XXX XXXXX XXX XXXXXXXXXX XX XXX XXXXXXXXXXX XXXXXXXX XX XXXXXXXX XX XXXXXXXX XX, XXXX. XXXXX XXXX XXXX XX XXXXXXXX XX XXX XXX XXX XXX XXXXXX XXX XXXXXXX XXXXXXXX XX XX.

XX XXXX XXXXX-XXXX XXX XXXXXX-XXXX XXXXXXXXXX XXXXXXXXXX XXXXXX (XXX), XXXXXXXXXXX XX XXX XXXXXX XXXXXXX XX XXXX XXX XX-XXXX XXXX XXX XXXXX XXXXXXX XX XXXX XXX XXX XXXXXX XXXXXXX XX XXXX.

XX XXXXXXXXX XX, XXXX, XX XXXXXXXXX XXXX XX XXXXXXXXX XX XXXX XX XXX XXX XXX XXXXXXX XX XXXXXXXXX XXXXXXXXX XXX XXXXXXXX XXXX XXXXXXXX XXXXX XXXX XXXXXXXXX.

XX XXXXXXXX X, XXXX, XX XXXXXXXXX XXXX XX XXXXXXXXX XX XXXX XX XXX XXX XXX XXXXXXX XX X XXXXXXXXX XXXXXXXXX XXX XXXXXXXX XXXX XXXXXXXXXX XXXXXXX XXXXXXXXXXXX. XX XXXXXXXX XX XXX XXX, XXX XXXXXXXXXXX XXXXX XX XXXXXXXXXX XXX XX XXXXXXXXXXX XXXXXXXX XXXX XXXXXX XXXXXXXXXXX XXXXXXXX XX XXXXXXXXX XXX XXXXXX XX XXXXX XXXX-XXXXXXXXXXX XXXXXXXX XXXXX XX XXXXXXXXXXX XXXXXXXX XXXXXXXXXX XXXXXXXX XXXXXXX. XX XXXX XX XXXXXXXX X XXXXXX XXXXX XXX XXXXX XX XXXXXXXX XXXX XXXXX XXXXXXXXX XXXXXXXXXXXX XXXXXXXXXX XX XXX XXXXX XXXX XX XXXX XXXX XXXX XXXXXXXX XXXXXXX XXXX XXXXXXXX XX XXXX XXXXXXXXXXXX XXX XXXXXXXXX.

XXX XXXXX XX XXXXXXXXXX XX XXXXXXX XXXXX XXX XXXXX (XXXXX X-XX) XX XXXXXXX XXXX XXXXXXXXXXXX XX XXXXXXXX XXXX XXXXX-XXXXX XXXXX XXXXXX. XXXXXX XXXX, XX XXXXXXXXX XXXX XXX XXXXX XXXXXXXX XX XXXX XXX XXXXX XXXXX XXXXXXXX, XXXXX XX XXXXXXXXXXXXXXX XXXX XX XXXXXXXXXXX XXXX XXXXXXXXXX XXXXXXXXX XXXXX XXXXXXX XXXXXXX XXXXXXXX XXX XXXX XXX XXXXX XXXXXXXX XXX XXXXXX XXXXXXX XXXX XXXXXXXX XX XX XXXXXXXXX XX XXXX XXXXXX XXXX XXXX XX XXX XXXXXXXXXX XXXXXXXXXXX. XX XXXX XXXXXXXXX XXXX XXX XXXXXXX XXXXXXXX XXXXXX XX XXX XX XXXXXXXXXX XXXXXX XXXXXX XX XXX XXXXXXX XXX. XX XXXXXXX XX, XXXX, XX XXXXXXXXX XXXX XXX XXXXX XXXXXXXX XX XXXX XXX XXXXXXX XX XXX XXXXX XXXXX XX XXXXX XXX XXXXXXXXXXXX XX XXXXX XX XXX-XXXXX XXXX. XXX XXXXX XXXXXX XX XXXX XXXXXXXXXXXX XXXX XXXXXX XX XXX XXXXXX XX XXXXXXX XXXXXXXXXXX XXXXXX. XX XXX XXXXXXXX XXXXXX XX XXXXXXX XXXXXXXXXXX XXXXXX XX XXXXXXX XX XXX XXXXX’X XXXXXXXXXXX XXXXXXXXXX XXXX XXX XXX XXXXXXXX XX XX XXX-XXXXX, XXXX XXX XXXXX XXXX XXXXXXXX XXX XXXXX XXX XX XXXXXXXXXX XXXX XXX XXXXX XXXXXXX XXXX XXXX XXXXXX XX XXXXX XXXXX XX XXX XXXXXX XXXXXXX XX XXXX.

XXXXX XXXXXXXXX, XX XXXX, XXXXXX XX XXXXX XXXXXXXXXX:

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X) +XXX XXXXX XXXXX (+XX%).
X) +XXXX XXXXXX/XXX XXXXX (+XX%).
X) +XXXX XX XXXXX (XXXXXXXXXXXX XX XXXXXXXXX)(+X%).

XXXXX XX XXXXX: +XXXX (+XX%).

XXXXXXX XXXXXXX:

XXXXXX: XXXXX XXXX XXXXXXXX XXXXXX, XXXX XX:
XXXXX XX XXXXXXXXX (XXXXXXXXXXX), XXXXX XX XXXXXXXX XX XXXXX X XXXXXXXXXXXX XXXXXXXXXX XXXX XX XXXXXX (XXXX-XXXXXXXX) XXXX XXXXXXXX XXX XX–XX% XX XXX XXXXXX XXXXXXX, XXXXXXXXX XX XXXXXXX XXXXXX XXXXXX XXXXXXXXXX XXX XXXX.XXXX XXXXXXXXXXX XXX XXXXXXXXX XXXXXX XX XXXXXX XX XXX XXXXXXXX (XXXXX-XXXXX) XXXXXX XXXXXX XXXXXXX XX XXXXXXX, XXXXXX, XXXXX, XXXXX XXX XXX XXXXXX XXXXXXX, XXX XXX XXXX XXXXXXXX XXXXXXX. XXX XX XXXXXXX, XXXXX XXXXXXXX XX XXXXXXXXX XXX XXXXXXXX XXXXXXXXX, XXX XXXXXXX’X XXXXXX XXXXXXXXXXX XX XXX XXXXXX XXXXXX XXXXXXXXXX XX X XXXX XXXXX XXXXXX XXXX. XX XXX XXXXXXXXXX XXXXXXX, XXXXXXXX XXXXX XXX XXXXXXXXX XXXXXXXX XXXXXXXX XXXXXX XXXX XX XXX XX XXX XX XXX XXX XXXX XXXXXXXX XXXXXXX. XXX XXXX XXXX XXX XXXXX-XXXXXX XXXXXXXXX (XXXX) XXXXX XXXXXXXX XX XXXX XXXX XXXX XXXXXXXXX XXXX XXXXXXXXX XX XXXXXX XXXXXX XXXX XXXXXX XXXXXXX XXXXX XXXXXXXXX XXXX-XXXXXXXX XXXXXXX XXX XXX XXXXXX XXX XXXX XXX XXXXXX XXXXXXX.XXXXX XXXXXXX XXX XX XXX XXXXXXXXXXX XXXXXXXX XXXXXXXXXX XXXXXXXXX XX XXX XXXXXXXXXX XX XXXX XXX XXXXX XXXX XXXX-XXXXXXXX XXXXXX XXXXXX XX XXX XXXXXX XX XXX XXXXXXX.XX XXX XXXXX XXXXXX XX XXXXXXXX XXX XXX XXX XX XXXXXXXXX XX XXXXXXXXXXX XXXX XXXXXXXX XXXXXXX (XXXXXXXXX XXXXXXXXX) XXX XXX XXXXXXXXX XX XXXXXXXX XXXX XXXXXXXXXX XXXXXX XXXXXX XXXX XX XXXX XXXX-XXXXXXXX XXX XXXXXXX XXXXXXXX-XXXXXXXX.

XXXXXX: XXXXX XXXX XXXXXX XXXXXX, XXXX XX:
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XXXXX XXX XXXXXXX XX XXX XXX XXXXXXXXXXXX XXXXXXXXX XXXXXXXXXX XX XXXXXXXX XXXX XXXX-XXXXXXXX XXXXXXXXXX XXXXXX XXXXXX XX XXXXXXXX XX XXXXX XXXXXXX XXXXXXXXXXX XXXXX XX XXXX. XXXX XXXXXXX XXXXXXXX XXXXXXX XX X XXXXX XX XXXXX XX XXXXXXXX XXXX XXXXXXXXXX XXXXXXXXXX XXXX-XXXXXXXX XXXXXX XXXXXX XX XXXXX XXXXXXXXXX XXXXXX XXXXXXXXXXX XXXXXXXXXX XXXXXXXX XXXX XXXX XX XXXXXXXXXXX XXXX XXXXXXXXX. XX XXX XXXXX XXX XXXXX XXXXX XXX XXXX XXX XXXXXXXXXX XXXX XXXXXXX XXX XXXXXXXXXX XXXX-XXXXXXXX XXXXXX XXXXXX XXXX XXXXXXX XXXXXXXXX XXXX XXXXXXXXX XX XXXXXXXX XXXXXXXXX, XXXXXXXXX XXX XXXXXXXXXX. XXX XXXXXXXXX XXXX XX XXXXXXXXXX XX XXXXX XXXXXX XXXXX XX XXXX XXXXX XXXXXXXXXXXX.

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XXXXXX: XXXXXXXXX XXXX XX-X, XXXXX X-X:
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…XX XXX XXXXXXXXX XXX XXXXX XXX XXXXXXXX XXXXXX XX XXXXXX XXXXXXXXX XX XXXX. XXXX XXXXXXX XX XXXXX XXXXXXXXX XX XXXXXXXXXXXXX XXXX XXXXX.

XX XXX XXXXXXXXX XXX X XXXXX XXX XXXXXXXX XXXXX XX XXXXXXXXX XXX XXXXXXX XX XXXXXXXXXXX XXXXXXX XX XXXXX-XXXX XXX XXXXXXXX XXXX-XXXXXXX XXXXXXXXXX XX. XXXXX XXXXXXXX XXX XXXXX XXXXXXXXX XX XXXXXXXXXXXXX XXXX XXXXX. XXXXX XXX XXXXXXXX XXXXXX XXXX XXXX XXXXXX XX XXXXX XXX XXXXX.

…XXXXXXXXXX XX XXXXX XXXXXXXXX XX XXXX-XXXXXXXX XXXXXXXXXX XX XXXXXXXX XXX XXXX XXXXXXXXXX XX XXXXXXXXX. XXXX XXXXXXX XX XXXXX XXXXXXXXX XX XXXXXXXXXXXXX XXXX XXXXX.

XXXXX XXXXXXXXX, XX XXXX, XXXXXX XX XXXXX XXXXXXXXXX:

XXXXXXXX:
X) +XXX XXXXX XXXXX (+XX%).
X) +XXXX XXXXXX/XXX XXXXX (+XX%).
X) +XXXX XX XXXXX (XXXXXXXXXXXX XX XXXXXXXXX)(+X%).

XXXXX XX XXXXX: +XXXX (+XX%).

XXXXXXX XXXXXXX:

XXXXXX: XXXXX XXXX XXXXXXXX XXXXXX, XXXX XX:
XX XXXX XXXXX XXXXXXXXX XX XXXXXXXXXX XXX XXXXXXXX XX XXX XXXXX’X XXXXXXX XXXXXXXX XX XXXXXXXXX XX XXXXX XXXXXX. XXXXX XX XXX XXXXXXXXXXXXXXX XXXXXXXX’X XXXXXXXX XXXXXXXXXX XXXX XX% XX XX.X XXXXXXX XXXXX XXXXXX XXX XXX XXXX, XX XX% XX XXXXX XXXXXXXXXXXXXX XXXXX, XXXX XXX XXX XXXXXX XXXXXXXXXXXX XXXXXX-XXXXX XXXXXX. XXXX XX XXXXXXXXXXX, XXX XXXXX XXXXXXXX XXX XXXXXXXXXXX XXXXXXXXXX XXX XXXXX XXXXXXXXX XXXXXXXXXXXX XXXXX XX XXXXXX XXXX XXXXXXXXX XXXXXXXXX XXXXXXX XXXXXXXXX XX XXXXXXX XXX XXXXXX XXXXXXXX XX XXXXXXXXX XXX XXXXX XX XXXXXXXXXX XXX XXXXX XXXXXXXXXX XXXXXXXXX XXXX XX XXXXXXXX/ XXXXXXX, XXXXXXX, XXXXXXXXX, XXXXXXX XXX XXXXXX XXX XX XXXXXXXXXX.

XXXXXX: XX XXXX XXXXXXX (X XXX XXXX):
XXXXXXXXX (XXXXXXXXXXX) XXXXXX XXXXX XXXXXX-XXXXX XXXXX XXXXXX (XX%) XXXXXXXXXX XXXX, XXX X XXXXX XX X.X XXXXXXX XXXXX XXXXXX. XXXXXX XXX XXXXXXXXXX XXXXXX XX XXXXX (XX%) XXX XX XXXXXXXXXX XXXXXX XXXXX XXXXXXXX XX XXXXXXXXX XXX XXXXX XXXXXX XXXXXX XX XXXXXXXX. XXXXX XXXXXX-XXXXX XXXXXX XXX XXXXXXXX XX XXX XXXXXX XXXXXX (X%), XXXXX XXXXXX-XXXXX XXXXX XXXX XXXXXXXX XX XXXXXX/XXX (XX%).

XXXXXXX XXXXXXXXX XXXXXXXXXXX XXXXXXX:

XXXXXX: XXXX XXXXXX XXXXXX, XXXX XX:
XX XXXXXXXX XXXX, XXXXXXXXX XXX XXXXXXXX XXX XXX XXXXXXXXXX XXXXXXXXXX XX XXXX-XXXXXXXXX XXXXXXXX XXXXXXX XX XXXX-XXXXXXXX XXXXXX XXXXXX, XXXXX XX X XXX-XXXX XXXXXXX XXXXXXXX XX X XXXXX XXXXXX XXXXX (XXXX). XXX XXXXXXX XXXXXX XXXX, XXXX XXX XXXXX XX XXXXXX XXXXXX-XX, XXX XXXX XX XXXXXXXXXX XXX XXXXX XXXXXXXXX XX XX% XXX XX%, XXXXXXXXXXXX, XX XXX XXXXX XXXXXXX XXXX XXXXXXXXX XXX XXX XXXX XX XXXXXXXX XXXX XXX XXXXX XXX XXXXXXXXX XXX XXXXXXX.

XXXX XX:
XXXXXX XX XXXX XXXXXXXXXXXXX XX XXXXXX XXXXX XXX XXXXXXX XXXXXXXXXXXXX XXXXXX XXX XXXXXXXXX XX XXXXXXX XXXXXX, XXXX XXXXXXX XXX XXXX XXXXXXXX XXXXXXXX XX XXXX.

XXXXXX: XXXX XXXXXXXX XXXXXX, XXXX XX:
XXXXXXX XXXXXXX XXX XXXXXXXXX XXXXXXXXXX XXXXXXXXX XX XXXXXXXXXXX XXXX XXXXXXX XX XXXXXXXXXX XX XXXXXXXX XXXX XXXX-XXXXXXXX XXXXXX XXXXXX. XX XXXXXXXX XX XXXX (XXX XXXXX, XXXXXXX), XXXXXXXXX XXX XXXXXXXXX (XXX XXXXX, XXXXXXXXXX), XXXXXXXXX XX XXXX XXXXX XXXXXXX XX X XXXXXX XXXXX XXX XXXXX (XXXXXX) XX XXXXXXXXXXX XXXX XXXXXXX XX XXX XXXXX-XXXX XXXXXXXXX XX XXXXXXXX XXXXXX XXXXXX. XXXXXXXXX XX XXXX XXXXX XXXXXXXXXXXX XX XXXX-XXXXXXXX XXXXXXXX XXXXXXX XXXXXX XX XXX XXXXX XXX XXXX XXXXX. XXXXXX XX% XX XXXXXXXX XXXX XXXXXXX XXXXXX XXXX XXXX-XXXXXXXX XXXXXXX.

XXXXXX: XXXXXXXXX XXXX XX-X, XXXX X:
XXXXXXXXX
XXXXXXXXX XX XXXXX XXXXXXXXX XXX XXX XXXXXXXXX XX XXXXXXXX XXXX XXXXX-XXXXX XXXX-XXXXXXXX XX XX XXXXXXX XXX XXXX XXXXXXXX XX XXXXXXXXX XXXX XXX XXXXX XXXXXXXX XX XXXXXXXXX. XXXX XXXXXXX XX XXXXX XXXXXXXXX XX XXXXXXXXXXXXX XXXX XXXXX.

XXXX XX:
XX XXXXXXX XX, XXXX, XXX XXX XXXXXXXX XXX XXXXXXXXX XXXXX, XXXXX XX XXX XXXX XXXXX, XXX XXX XXXXXXXXX XX XXXXXXXX XXXX XXXXX-XXXXX XXXX-XXXXXXXX XX XX XXXXXXX XXXXXXXXX XXX XXXXXXXX XXXX XXXX-XXXXXXXX XX.

XX XXX XX, XXXX, XXX XXX XXXXXXXX XXX XXXXXXXXX XXXXX, XXXXX XX XXX XXXXX XXX XXXXX, XXX XXX XXXXXXXXX XX XXXXXXXX XXXX XXXXX-XXXXX XXXX-XXXXXXXX XX XX XXXXXXX XXXXXXXXX XXXXX XXXX XXXXXXXXX XXX XXXXXXXXXXX. XXXXXXXXX XXXX XXX XXX XX XXXXXXXXXXXX XXX XXX XXXX XX XX XXXXX-XXXXX-XXXX XXXXXX XXXXXXXX, XXXXXXX XX XXXXXX.

Shaded Cells

A shaded cell signifies potentially incomplete data. E.g. A shaded cell in "Change (+/-)" means there is no corresponding value, i.e. there is data for 2001, but no data for 2000. This could signify a product launch, first time disclosure of sales, a product acquisition or missing data.

A shaded cell containing n/a signifies valid data followed by blank or zero values. E.g. A shaded cell containing n/a in "Change (+/-)" means a value is present for 2000, but blank for 2001. This could signify a product disposal / withdrawal, discontinuation of disclosure or missing data.

Company Specific NamePrescription products; Genentech; Chugai Rx sales

Company Specific NameCentral Nervous System

XXXXXXXX XX XXXX:
X) +XXXXX XXXXX XXXXXXXXXXXXXXX.
X) +XXXXX XXXXXXXXX.
X) +XXXX XXXXXX.

XXXXXXXX XX XXXX:
X) +XXXX XXXXXXX XXXXXXX XXXXXX (XXXXXXXXXX XXXXX XX X% XX XXXXX'X XX XXXXXXXXXXXX XXXXX).

XXXXXXXX XX XXXX:
X) +XXXXX XXXXX XXXXXXXXXXXXXXX.
X) +XXXXX XXXXXXXXX.
X) +XXXX XXXXXX.

Company Specific NameDermatology

XXXXXXXXXXXXXX XXXXXXX:
XXXXX'X XXXXXXXXX XXXXXXXX & XXXXXXXXXXXXXXX XXXXXXXXXXX XXXX XXXXX XXX XXX XXXXXXXX XXX XX XXXXXX XXXXXXXXXX XXXX XXXXXX.

XXXXX'X XXXXXXXXX XXXXXXXXXXX XXXX XXXXX XXX (XX XXXX):
X) +XXXXX XXXXXXXX (XX% XX XXXXX'X XXXXXXXXXXXX XXXXX). XXXXXXXX XXXXXX & XXXXXXXXX
X) +XXXX XXXXXXXXXXXX XXX XXXXXXXXXX XXXXXXXX, XXXXXXXXXXXXXXX (X% XX XXXXX'X XXXXXXXXXXXX XXXXX).

XXXX:
X) +XXXX XXXXXXX XXXXX (XXXXX XXXXXXXXXX XX XXXXXXXX XXX XXXXXXXXXXXXXX XXXXXXXXXX XX "XXXXXXXX & XXXXXXXXXXXXXXXX").
XXXXX
X) +XXX XXXXXXXXX XXXXXX XXXXX (XXXXX XXXXXXXXXX XX XXXXXXXX XXX XXXXXXXXXXXXXX XXXXXXXXXX XX "XXXXXX-XXXXXXXXXX/ XXXX-XXXXXXX").
X) XXXXXX XXXXXXXX XXXXXXXX

XXXXXXXX XX XXXX:
X) + XXXXXXXXXXX (X% XX XXXXX'X XXXXXXXXXXXX XXXXX).

XXXXXXXX XX XXXX:
X) +XXX XXXXXXXXXX XXXXXXX (X% XX XXXXX'X XXXXXXXXXXXX XXXXX).
X) +XXXX XXXXXXXX (X% XX XXXXX'X XXXXXXXXXXXX XXXXX).
XXXXX:
X) +XXXX XXXXXXX XXXXX (XXXXX XXXXXXXXXX XX XXXXXXXX XXX XXXXXXXXXXXXXX XXXXXXXXXX XX "XXXXXXXX & XXXXXXXXXXXXXXXX").

XXXXXXXX XXXXX XX XXXXXX.
X XXX XXXX: XXXXXXXX XX.X% XXXXXXXX XX XXXXXX XXX XXX X.XXX ($X.XXX).
XXXXX XXXXX XXXXXXXXXXXX XXXXXX XXXX X XXX XXXX.

XXXXXX XXXXX XXXXX XXXXXXXX XX XXXXXX XXXX XXXX XXXXXXXX XX XXXXX XXXXXX-XXXXXXXX (XXXX XXX XXXXXXX XX XX XXXXXXXXX XX XXXXX).